EBOO ozone therapy costs $900 to $1,500 per session, making it the most expensive form of ozone therapy available. EBOO (Extracorporeal Blood Oxygenation and Ozonation) filters and ozonates your entire blood volume outside the body, which requires specialized equipment, trained staff, and 1 to 3 hours of treatment time. This guide breaks down what EBOO costs, why it is priced higher than other ozone modalities, package pricing, and whether the premium is worth it.
Key Takeaways
- Single EBOO sessions cost $900 to $1,500. Package pricing brings per-session costs to $800 to $1,200.
- A full treatment course (6 to 10 sessions) typically costs $5,400 to $12,000 total.
- EBOO is 3 to 10 times more expensive than MAH and 1.5 to 2 times more than 10-pass ozone.
- Insurance does not cover EBOO. All costs are out of pocket.
- Equipment costs ($30,000 to $80,000) and staffing requirements drive the higher price.
What Does EBOO Ozone Therapy Cost?
EBOO pricing varies by clinic, location, and what is included in the session. Here is what you can expect to pay across the United States:
| Pricing Structure | Cost Range |
|---|---|
| Single EBOO session | $900 to $1,500 |
| 3-session package | $2,400 to $3,900 |
| 5-session package | $3,900 to $6,000 |
| 10-session package | $7,500 to $12,000 |
| Maintenance sessions (monthly) | $800 to $1,200 |
Real-world clinic pricing examples from across the US:
- A Florida clinic charges $875 per session, or $2,400 for 3 sessions and $3,900 for 5 sessions
- A Las Vegas practice prices EBOO at $1,400 per session, or 4 sessions for $4,800
- A Virginia clinic offers EBOO Quantum+ (ozone with ultraviolet blood irradiation and methylene blue) for $795
- An Oregon provider charges $830 per session
Why EBOO Is the Most Expensive Ozone Modality
EBOO costs significantly more than other forms of ozone therapy for several concrete reasons:
Equipment cost. An EBOO machine costs $30,000 to $80,000. The device includes a dialysis-type filter, ozone generator, blood pumps, and monitoring systems. Compare this to a standard ozone generator for MAH that costs $3,000 to $8,000.
Disposable supplies. Each EBOO session requires a single-use extracorporeal circuit (tubing set, filter, connectors) that costs the clinic $100 to $300. These cannot be reused for safety reasons.
Time. An EBOO session takes 1 to 3 hours, during which a trained practitioner monitors the patient continuously. A standard MAH session takes 30 to 45 minutes with less monitoring.
Training and staffing. EBOO requires practitioners with specific training in extracorporeal blood handling. The procedure involves establishing IV access in both arms (blood is drawn from one and returned to the other), managing anticoagulation, and monitoring for adverse reactions.
Volume of blood treated. EBOO processes your entire blood volume (approximately 4,800 mL) during a single session. By comparison, MAH treats only 100 to 250 mL of blood per session.1
EBOO vs. MAH vs. 10-Pass: Cost Comparison
Understanding how EBOO pricing compares to other IV ozone modalities helps you evaluate whether the premium is justified:
| Feature | MAH | 10-Pass | EBOO |
|---|---|---|---|
| Cost per session | $150 to $300 | $750 to $900 | $900 to $1,500 |
| Blood volume treated | 100 to 250 mL | 2,000 mL (200 mL x 10) | ~4,800 mL (full volume) |
| Ozone dose delivered | Low (single pass) | High (10 consecutive passes) | Highest (continuous circulation) |
| Session duration | 30 to 45 min | 60 to 90 min | 60 to 180 min |
| Filtration included | No | No | Yes (dialysis-type filter) |
| IV access points | 1 | 1 | 2 (both arms) |
| Typical course (sessions) | 10 to 20 | 6 to 10 | 6 to 10 |
The 10-pass method delivers 30 to 60 times more ozone than a single MAH treatment. EBOO goes further by circulating and filtering the full blood volume while infusing ozone continuously.
“EBOO can treat up to 4,800 mL of heparinized blood in 1 hour of extracorporeal circulation without technical or clinical problems.”
Di Paolo et al., International Journal of Artificial Organs, 2005
What Is Included in the Price?
Before comparing clinics on price alone, understand what each clinic includes in their EBOO session fee:
Standard inclusions:
- Pre-treatment vitals and health assessment
- IV access setup (both arms)
- The EBOO procedure itself (1 to 3 hours)
- Practitioner monitoring throughout
- Post-treatment observation (15 to 30 minutes)
- Disposable circuit and supplies
Common add-ons (may or may not be included in the quoted price):
- Ultraviolet blood irradiation (UBI/UVBI): +$100 to $200
- Methylene blue infusion: +$50 to $150
- Glutathione push: +$50 to $100
- IV vitamin C drip: +$100 to $250
- Initial consultation: +$150 to $400 (often waived with package purchase)
- Blood work (pre-screening labs): +$100 to $300
Some clinics quote an all-inclusive price. Others quote a base price and add extras. Always ask for an itemized breakdown before committing.
Geographic Price Variation
EBOO ozone therapy cost varies by region:
- Major metropolitan areas (NYC, LA, Miami): Tend toward the high end ($1,200 to $1,500 per session)
- Mid-size cities (Austin, Denver, Charlotte): Mid-range ($900 to $1,200 per session)
- Smaller cities and rural areas: Often lower ($800 to $1,000 per session), but fewer clinics offer EBOO
Medical clinics with physician oversight generally charge more than wellness spas or naturopathic offices. However, physician-supervised EBOO may be safer, particularly for patients with complex health conditions.
Insurance Coverage for EBOO
EBOO ozone therapy is not covered by insurance. No major health insurance company in the United States covers EBOO, including:
- Medicare and Medicaid
- Blue Cross Blue Shield
- UnitedHealthcare
- Aetna
- Cigna
Ozone therapy is classified as experimental or investigational by US insurers. This applies to all forms of ozone therapy, not just EBOO.
Payment options: Most EBOO clinics accept credit cards and offer payment plans. Some accept HSA (Health Savings Account) and FSA (Flexible Spending Account) funds since ozone therapy may qualify as a medical expense. Check with your HSA/FSA administrator to confirm eligibility.
Is EBOO Worth the Premium?
Whether EBOO is worth 3 to 10 times the cost of MAH depends on your situation:
EBOO may be worth considering if:
- You have a serious chronic condition (Lyme disease, chronic infections, autoimmune conditions) that has not responded to other ozone modalities
- You want the blood filtration component (removes debris, immune complexes, inflammatory byproducts)
- You have tried MAH and 10-pass without adequate results
- You prefer fewer sessions at higher intensity over many sessions at lower intensity
MAH or 10-pass may be better if:
- You are new to ozone therapy and want to start with a less intensive (and less expensive) modality
- Budget is a primary concern
- Your condition responds well to standard ozone protocols
- You prefer gradual treatment over intensive sessions
How to Budget for EBOO Treatment
If you are considering EBOO, here is a realistic budgeting framework:
Initial treatment course:
- Initial consultation: $150 to $400
- Pre-treatment labs: $100 to $300
- 6 to 10 EBOO sessions (package pricing): $4,800 to $10,000
- Total initial investment: $5,050 to $10,700
Maintenance phase:
- Monthly maintenance session: $800 to $1,200
- Annual maintenance cost: $9,600 to $14,400
Cost-saving strategies:
- Ask about package discounts (5 to 20% savings)
- Inquire about introductory pricing for new patients
- Consider combining EBOO with at-home ozone therapies (rectal insufflation) to extend the time between clinic visits
- Use HSA/FSA funds if eligible
- Ask about referral discounts
For a broader view of ozone therapy costs across all modalities, see our complete pricing guide.
The Clinical Evidence
EBOO has been used clinically for over two decades. The most notable published research:
A controlled trial involving 28 patients with peripheral artery disease compared EBOO to intravenous prostacyclin. Patients treated with EBOO showed highly significant regression of skin lesions compared to the prostacyclin group.1
The technique was tested extensively, with over 1,200 treatments performed in 82 patients. The high-efficiency apparatus can treat up to 4,800 mL of heparinized blood in 1 hour of extracorporeal circulation without technical or clinical problems.2
In terms of biochemical effects, an EBOO session produces a 4 to 5-fold increase in thiobarbituric acid reactants (markers of controlled oxidative stress) without any appreciable red blood cell damage.3
EBOO has been performed for at least two decades with no published reports of injuries, establishing a strong safety record.4
Frequently Asked Questions
How many EBOO sessions do I need?
Most practitioners recommend 6 to 10 sessions for an initial treatment course, followed by monthly maintenance. The exact number depends on your condition, severity, and response to treatment. Some patients see improvement after 3 sessions; others need the full course.
Can I negotiate EBOO pricing?
Yes. Many clinics are open to discussing pricing, especially if you commit to a package upfront. Ask about new patient specials, referral discounts, or payment plans.
Why do some clinics charge less than $900?
Some lower-priced clinics may be offering a modified version of EBOO (sometimes called “ozone dialysis”) with different equipment. Ask specifically about the equipment used, blood volume treated, and whether the session includes filtration.
Is EBOO tax-deductible?
Medical expenses that exceed 7.5% of your adjusted gross income may be tax-deductible in the US. Ozone therapy expenses may qualify. Consult a tax professional for advice specific to your situation.
The Bottom Line
EBOO is the premium tier of ozone therapy, and its pricing reflects the equipment investment, consumable costs, time commitment, and clinical complexity involved. At $900 to $1,500 per session, it is a significant investment. Package pricing can bring per-session costs down to the $800 to $1,200 range.
For patients who have tried less intensive ozone modalities without adequate results, or who want the added benefit of blood filtration, EBOO offers the most comprehensive ozone treatment available. For those new to ozone therapy or working with a tighter budget, starting with MAH ($150 to $300 per session) is a more accessible entry point.
- Di Paolo N, et al. Extracorporeal blood oxygenation and ozonation (EBOO): a controlled trial in patients with peripheral artery disease. International Journal of Artificial Organs. 2005;28(10):1039-1050. DOI: 10.1177/039139880502801012
- Di Paolo N, et al. Extracorporeal blood oxygenation and ozonation (EBOO) in man: preliminary report. International Journal of Artificial Organs. 2000;23(2):131-141. DOI: 10.1177/039139880002300212
- Di Paolo N, et al. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Report. 2005;10(3):121-130. DOI: 10.1179/135100005X38888
- Rowen RJ. Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment. Journal of Ozone Therapy. 2022. DOI: 10.7203/jo3t.6.2.2022.25750
Medical Disclaimer
The content on BaricBoost.com is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Author
Seph Fontane Pennock is the founder of BaricBoost.com and Regenerated.com, a clinic directory for regenerative medicine serving 10,000+ providers across the United States. He previously built and sold PositivePsychology.com, which grew to 19 million users and became the largest evidence-based positive psychology resource on the web. Seph brings direct experience as an HBOT patient, having completed protocols at clinics across three continents while navigating mold illness, systemic inflammation, and autoimmune conditions. His treatment journey includes hyperbaric oxygen therapy, peptide protocols, NAD+ therapy, and consultations with specialists from Dubai to Cape Town to Mexico. This combination of entrepreneurial track record and lived patient experience shapes everything published on BaricBoost.com. Every article is grounded in peer-reviewed research, informed by real clinical encounters, and written for patients making high-stakes treatment decisions. Seph's focus is on bringing transparency, scientific rigor, and practical guidance to the hyperbaric oxygen therapy space.
